Case Report

A Malignant Squeeze: A Rare Cause of Cardiac Tamponade

Table 1

Reports of primary cardiac lymphoma causing cardiac tamponade.

Article (language, PMID)DescriptionHighlights

Parato VM, Muscente F, Scarano M. Primary cardiac lymphoma: a case report. G Ital Cardiol (Rome). 2017 Jan; 18(1): 11–13 (Italian, 28287210)35-year-old immunocompromised patient presented with signs and symptoms of tamponade. Echocardiography revealed lateral AV mass with large pericardial effusion. Patient had surgical excision of mass followed by chemotherapy that induced complete remission at 6 months.
Tzachanis D, Dewar R, Luptakova K, Chang JD, et al. Primary cardiac Burkitt lymphoma presenting with abdominal pain (English, 25431699)44-year-old female presented with abdominal bloating who was found to have a large pericardial effusion with tamponade physiology. Pericardial fluid studies led to diagnosis of cardiac Burkitt lymphoma.Primary Burkitt lymphoma
Frikha Z, Abid L, Abid D, Mallek S, et al. Cardiac tamponade and paroxysmal third-degree atrioventricular block revealing a primary cardiac non-Hodgkin large B-cell lymphoma of the right ventricle: a case report. J Med Case Rep. 2011 Sep 5; 5: 433 (English, 21892927)64-year-old immunocompromised male presented with cardiac tamponade as well as paroxysmal third-degree AV block. He was found to have a large RV mass. Following excision, histology confirmed non-Hodgkin large B-cell lymphoma.Primary non-Hodgkin large B-cell lymphoma 3rd-degree AV block
Houchaymi Z, Helou S, Ballout J. Pericardial tamponade and third-degree atrioventricular block revealing a primary cardiac lymphoma. Rev Med Interne. 2010 Nov; 31 (11): e4-6 (French, 20605278)78-year-old immunocompetent male presented with pericardial tamponade and third-degree AV block. Biopsy of the cardiac tumor showed non-Hodgkin large B-Cell lymphoma.Primary non-Hodgkin large B-cell lymphoma 3rd-degree AV block
Chiba Y, Oka K, Saito H, et al. Primary cardiac B-cell lymphoma presented as heart tamponade and atrioventricular block: a case report. Acta Cytol. 2010 Jan–Feb; 54 (1): 79–81 (English, 20306995)49-year-old male with cardiac tamponade and AV block. Pericardial effusion and transvenous biopsy confirmed diagnosis of diffuse large B-cell lymphoma. He underwent chemotherapy and permanent pacemaker placement.Diffuse large B-cell lymphoma AV block
Legault S, Couture C, Bourgault C, et al. Primary cardiac Burkitt-like lymphoma of the right atrium74-year-old male with dyspnea found to have a large pericardial effusion with tamponade physiology. Found on pericardial fluid studies and biopsy to have Burkitt-like PCL.Burkitt-like PCL
Ling LF, Chai P, Kee AC, et al. Primary cardiac lymphoma presenting with cardiac tamponade. Am Heart Hosp J. 2009 Winter; 7 (2): E125-7 (English, 19279985)55-year-old immunocompetent man presented with pyrexia initially and was found later to have cardiac tamponade. He was diagnosed with PCL.
Gosev I, Siric F, Gasparovic H, et al. Surgical treatment of a primary cardiac lymphoma presenting with tamponade physiology (English, 16846425)67-year-old immunocompetent presented with dyspnea. Found to have tamponade physiology on echocardiography. Surgical biopsy confirmed diffuse large B-cell lymphoma of centroblastic subtype.Diffuse large B-cell lymphoma of centroblastic subtype
Surgical diagnosis, no pericardiocentesis performed
Wilhite DB, Quigley RL. Occult cardiac lymphoma presenting with cardiac tamponade. Tex Heart Inst. J. 2003; 30 (1): 62–4 (English, 12638674)83-year-old Filipino male with dyspnea found on echocardiogram to have a large, homogenous pericardial effusion with RA collapse. He was treated with subxiphoid pericardiostomy and had the pericardial drain removed the next day as he clinically improved. He returned two weeks later with same symptoms and again found to have reaccumulating pericardial fluid requiring urgent anterior pericardiectomy.Failure of traditional pericardiostomy
Menotti A, Imperadore F, Pelosi G. et al. Heart rupture at the right atrial level as the first manifestation of malignant lymphoma. Cardiologia. 1996 Jan;41(1):65–7 (Italian, 8697472)Malignant lymphoma presenting as cardiac tamponade due to right atrial rupture.Right atrial rupture causing the tamponade
Roller MB, Manoharan A, Lvoff R. Primary cardiac lymphoma. Acta Haematol. 1991; 85 (1): 47–48 (English, 2011932)Elderly male with cardiac tamponade found on pericardial fluid analysis to have PCL.
Nagamine K, Noda H. Two cases cardiac lymphoma presenting with pericardial effusion and tamponade. Jpn Circ. J. 1990 Sep; 54 (9): 1158–64 (English, 2266577)Two cases of males in their 70s presenting with dyspnea who were found to have pericardial effusion with tamponade physiology on echocardiogram.
Pozniak AL, Thomas RD, Hobbs CB, et al. Primary malignant lymphoma of the heart. Antemorten cytologic diagnosis. Acta Cytol. 1986 Nov–Dec; 30 (6): 662–4. (English, 3466501)Patient who presented with ventricular arrhythmias and was found to have pericardial effusion with impairment of LV contraction. Postmortem examination showed malignant lymphoma confined to myocardium.
Patel J, Melly L, Sheppard MN. Primary cardiac lymphoma: B- and T-cell cases at a specialist UK centreCase series of six patients presenting with wide spectrum of symptoms. Most cases involved 2 or more chambers of the heart. Presentations included conduction disturbances, effusion, valvular dysfunction, heart failure, stroke, and sudden death.Clinical presentation of PCL (B- and T-cells)