Case Report

Primary CNS Burkitt Lymphoma: A Case Report of a 55-Year-Old Cerebral Palsy Patient

Table 1

Reported PCNSBL cases. Cy: cyclophosphamide; OS: overall survival; WBRT: whole brain radiation therapy; CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisone; Dex: dexamethasone; IVIG: intravenous immunoglobulin; MTX: methotrexate.

AuthorYearAge/sexHow it is diagnosed (LP versus mass)Treatment and OS

Gawish [18]19768/MLeft frontoparietal mass extending across midline and through the skullComplete resection with recurrence. Subtotal resection with Cy. OS of 3 years
Valsamis et al. [19]19766 m/MLeft parietal, bilateral temporal, and post pituitary mass with abdominal and periaortic nodal involvementResection, steroids, WBRT, and spinal irradiation with recurrence, IT MTX. OS of 23 months
Tanaka et al. [20]197749/MRight thalamus to midbrain massSubtotal resection. OS of 4.5 years
Tanaka et al. [20]197758/MRight temporal massSubtotal resection. Recurrence. OS 3 months
Tanaka et al. [20]197742/MLeft deep parietal to occipital massPred with partial resection. Recurrence. Vincristine and Cy with radiation. Vincristine, bleomycin, Cy, steroids. OS of 2.5 years
Giromini et al. [11]198111/MLeft temporooccipital massComplete resection
Hegedüs [21]198450/FRight lower parietal lobe massPost mortem finding
Kobayashi [22]198455/FRight temporoparietal massComplete resection. Recurrence with reresection. OS of 2 months
Pui et al. [23]19856/MT2-5 massLaminectomy and CHOP (without prednisone). OS > 2 years
Pui et al. [23]19857/MC7-T4 massLaminectomy, radiation, dex, and Cy. Recurrence. OS of 5 months
Pui et al. [23]198512/MT7-10 massLaminectomy, CHOP (substituting dex for prednisone). OS of 4 months
Mizugami et al. [24]19876/MT10 massNear complete resection, radiation, and chemotherapy. Leukemic transformation then CSF recurrence. IT MTX and cranial irradiation. OS of 20 months
Mizugami et al. [24]19875/MEpidural T12-L4 massNear complete resection, radiation, and chemotherapy with recurrence. OS of 7 months
Mizugami et al. [24]19877/FT11 massNear complete resection. Spinal radiation and chemotherapy with progression of disease. OS of 3 months
Shigemori et al. [25]199149/FLeft frontal lobe massResection, radiation, CHOP, and IT MTX. OS of >6 months
Tekkök et al. [12]19915/MParasellar mass, extending to bilateral sphenoids and sella turcicaPartial resection, craniospinal radiation, CHOP, and IT MTX/cytarabine/prednisone. OS > 18 months
Toren et al. [26]19946/FCSFSteroids, IVIG, doxorubicin, vincristine, HD MTX, with IT MTX, cytarabine, and hydrocortisone. Changed to CHOP with MTX and IT MTX, cytarabine, hydrocortisone. OS of >2 years
Mora and Wollner [7]199918/MT11 massLaminectomy with CHOP substitute daunorubicin for doxorubicin and radiation. Relapse and refused further treatment. OS > 8 months
Mora and Wollner [7]19999/MEpidural T9-11 massLaminectomy, dex, radiation, and CHOP (substituting daunorubicin for doxorubicin). Recurrence and given chemotherapy via LSA3 protocol. Second recurrence, received palliative radiation. OS > 1 year
Spath-Schwalbe et al. [27]199940/MCerebellum and pons massesMTX and WBRT. OS > 1 year
Wilkening et al. [28]200143/FL2-3 epidural tumor involving the dura and cauda equinaComplete resection, radiation, IT MTX, and MTX with ifosfamide and CHOP (with dex substituted for prednisone). OS of >2 years
Monabati et al. [29]200249/FRight parietal massComplete resection, CHOP, and craniospinal radiation. Refused further treatment. OS of >6 months
Daley et al. [30]200313/FL1-2 epidural massComplete excision, CHOP with MTX, and IT MTX and cytarabine and steroids. OS of >5 years
Shehu [31]20038/MLeft temporal and right orbit massesCy, vincristine, and MTX with IT cytosine arabinoside. OS of 11 months
Abel et al. [32]200650/MCentral and right thalamus massUnknown
Gobbato et al. [15]200638/MRight frontotemporoparietal subdural massCraniotomy. OS of 11 days
Kozáková et al. [33]200860/FSellar/pituitary massComplete resection
Gu et al. [34]201075/FThird and left lateral ventricle massesWBRT. OS of >9 months
Takasu et al. [35]201071/MHypothalamus and third ventricle massPartial resection and WBRT
Jiang et al. [36]201114/MRight lateral ventricle massComplete resection, radiation, and MTX, vincristine, predisone, and leucovorin. OS of >18 months
Lim et al. [10]201143/FMedulla oblongata mass, CSF involvementMTX, vincristine, and procarbazine with IT MTX and WBRT. OS of 7 months
Akhaddar et al. [37]201213/FRight infratemporal and cavernous/maxillary/sphenoethmoidal sinus massChemotherapy
Jiang et al. [38]201269/MRight temporal and occipital lobe, cervical spine, and cauda equina masses; CSF involvementDLBCL/BL subtype. WBRT, spinal radiation with recurrence. HD MTX and cytarabine with rituximab
Yoon et al. [39]201210/MSuprasellar, cerebellum, and 3rd ventricle masses; CSF involvementHD MTX and cytarabine with IT cytarabine, MTX, and hydrocortisone. OS of >7 years
Yoon et al. [39]201232 m/MSellar mass extending to orbit/sphenoid, CSF involvementHD MTX and cytarabine with IT cytarabine, MTX, and hydrocortisone. Relapse, treated with IT cytarabine, MTX, and hydrocortisone with WBRT and spinal radiation. Then received prednisone, vincristine, and cyclophosphamide with IT. OS of 9 months
Alabdulsalam et al. [40]201418/M4th ventricle massCraniotomy with HD MTX with rituximab-CHOP and IT MTX, cytarabine, and hydrocortisone. OS of >18 months