Ipilimumab- and Nivolumab-Induced Colitis Causing Severe Hypokalemia and QTc Prolongation

Table 1

Common Terminology Criteria for Adverse Events grading scale in immune checkpoint inhibitor-induced colitis and diarrhea.

	Colitis	Diarrhea
Grade 1	Asymptomatic	Increase of <4 stools/day
Grade 2	Abdominal pain, mucus, blood in stool	Increase of 4-6 stools/day
Grade 3	Severe pain, fever, peritoneal signs	Increase of ≥7 stools/day
Grade 4	Life-threatening consequences (perforation, ischemia, necrosis, bleeding, toxic megacolon)	Life-threatening consequences such as hemodynamic collapse
Grade 5	Death	Death