Macular Hole Progression following Ocriplasmin Intravitreal Injection

Figure 1

Spectral-domain optical coherence tomography (SD-OCT) 1 day prior (a), 14 days after (b), and 35 days after (c) intravitreal ocriplasmin injection. (a) Prior to ocriplasmin injection, there is vitreomacular adhesion (VMA), with an underlying macular hole (240 µm diameter) involving the outer retinal layers. (b) 14 days after ocriplasmin injection, there is a resolution of VMA with enlargement of macular hole (540 µm diameter), which is now at full thickness. (c) 35 days after ocriplasmin injections, the full thickness hole persists (556 µm diameter).

(a)

(b)

(c)