Ophthalmic Manifestations of Hematopoietic Malignancy

Table 2

Differential diagnosis of optic nerve invasion.

	Disc swelling	Fundus status	Medical history	MRI findings	Pathology
Optic nerve invasion	Severe	Sometimes accompanied retinal hemorrhage and subretinal fluid	Cancer	Tram truck sign and swelling of optic nerve	Invasion of tumor cell accompanied with infarction
Optic neuritis	In various ways from mild to severe	Mainly disc swelling	Multiple sclerosis	High T2 signal, demyelination, and cloud-like enhancement	Immune response