Retinal Toxicity after Initial Administration of Nivolumab and Ipilimumab

Figure 3

SD-OCT of the macula at initial presentation. (a, b) SD-OCT demonstrates pachychoroidal changes (choroidal thickness of 505 μm in the right eye and 510 μm in the left eye) with discrete choroidal folds (white arrowheads) and subretinal fluid bilaterally, typically seen in immune checkpoint inhibitor- (ICI-) induced Vogt-Koyanagi-Harada- (VKH-) like uveitis. The most distinctive finding in this OCT assessment is the bacillary layer detachment with a dissection of the photoreceptor inner and outer segment in both eyes (white star), apparently more extensive in the right eye.

(a)

(b)