Managing an Acute and Chronic Periprosthetic Infection

Table 2

Diagnostic criteria for periprosthetic infections. For the diagnosis, 1 major criterion or 4 minor criteria are required [4, 13].

Major criteria	Acute: minor criteria	Chronic: minor criteria
Fistula (sinus tract)	CRP > 100 mg/L	CRP > 10 mg/L, ESR > 30
Two positive cultures for 1 microorganism(tissue or fluid)	Sinovial fluid WBC > 10,000 cells/µL	Sinovial fluid WBC > 3000 cells/µL
	Neutrophils > 90% on synovial fluid	Neutrophils > 80% on synovial fluid
	Purulence	Purulence
	1 positive culture (tissue or fluid)	1 positive culture (tissue or fluid)
	>5 neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at ×400 magnification	>5 neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at ×400 magnification