Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome

Table 1

Late reported pigmented villonodular synovitis.

Title	Author	Revue	Year	Noonan syndrome	Gene involved	MRI	Histology: MGCL in cellular fibrous tissue	Localisation	Treatment
“Pigmented Villonodular Synovitis of the Knee Joint: A Case Report” [7]	Kapoor et al.	Open Access Case Knee Joint: A Case Report	2016	—	NA	+	+	Left knee	Subtotal synovectomy
“SOS1 and PTPN11 Mutations in Five Cases of Noonan Syndrome with Multiple Giant Cell Lesions” [13]	Beneteau et al.	European Journal of Human Genetics	2009	+	SOS1	+	+	Left ankle	NA
“Pigmented Villonodular Synovitis in a Patient with Noonan Syndrome and SOS1 Gene Mutation” [14]	Mascheroni et al.	American Journal of Medical Genetics	2008	+	SOS 1 (R552S mutation)	+	+	Right ankle	Synovectomy

NA: information not available; MRI: magnetic resonance imaging; MRI +: nodular synovial proliferation with deposit of hemosiderin and joint effusion.