A Case of Radiation-Induced Multifocal Laryngeal Angiosarcoma Presenting as a Diagnostic Dilemma

Table 1

Cases that fulfill diagnostic criteria for radiation-induced angiosarcoma of the larynx.

Author	Initial primary	RT	Latency	Pre-op biopsy	Final pathology	Recurrence/multifocality	Survival
Thomas 1979 [1]	Vocal cord SCCA	70 Gy	11 years	Dysplasia with dilation of capillaries and lymphatics, no infiltrative growth	Supraglottic; Angiosarcoma	Yes, local recurrence,; no multifocal lesions, had pharyngocutaneous fistula	13 months s/p partial pharyngolaryngectomy, final pathology angiosarcoma
Miura et al. 2003 [2]	Supraglottis SCCA, cervical TB	68.4 Gy; unknown; 42 years	10 years	Initial biopsy interpreted as SCCA	Supraglottic; Angiosarcoma	Skin, breast and muscle	3 years and six months after laryngectomy followed by excision and chemo for metastatic lesions
Current case	Unknown primary SCCA	59.4 Gy	20 years	Initial biopsy inconclusive × 3, 4th biopsy angiosarcoma	Supraglottic; Angiosarcoma	Yes, 2 foci epiglottis and base of tongue,; yeast recurrence	2 years after narrow-field laryngectomy