Table 1: Cases that fulfill diagnostic criteria for radiation-induced angiosarcoma of the larynx.

AuthorInitial primaryRTLatencyPre-op biopsyFinal pathologyRecurrence/multifocalitySurvival

Thomas 1979 [1]Vocal cord SCCA70 Gy11 yearsDysplasia with dilation of capillaries and lymphatics, no infiltrative growthSupraglottic
Angiosarcoma
Yes, local recurrence,
no multifocal lesions, had pharyngocutaneous fistula
13 months s/p partial pharyngolaryngectomy, final pathology angiosarcoma

Miura et al. 2003 [2]Supraglottis SCCA, cervical TB68.4 Gy;
unknown
42 years
10 yearsInitial biopsy interpreted as SCCASupraglottic
Angiosarcoma
Skin, breast and muscle3 years and six months after laryngectomy followed by excision and chemo for metastatic lesions

Current caseUnknown primary SCCA59.4 Gy20 yearsInitial biopsy inconclusive × 3, 4th biopsy angiosarcomaSupraglottic
Angiosarcoma
Yes, 2 foci epiglottis and base of tongue,
yeast recurrence
2 years after narrow-field laryngectomy