- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Case Reports in Otolaryngology
Volume 2013 (2013), Article ID 920352, 3 pages
Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis
Ear, Nose & Throat Department, Southern Health, Monash Medical Centre, 246 Clayton Road, Melbourne, VIC 3168, Australia
Received 30 April 2013; Accepted 2 June 2013
Academic Editors: J. I. De Diego and A. Harimaya
Copyright © 2013 Rebecca Sin Mei Lim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.
1. Melioidosis of the Nose
A 51-year-old Caucasian man presented to a tertiary hospital in Melbourne, Australia, with 7 days of headache, myalgia, fevers, and sweats. There was cellulitis affecting the right side face with purulent discharge from a tender right nostril. He had poorly controlled type 2 diabetes requiring insulin and chronic hepatitis B. He was a 25-pack-year smoker, drank >6 standard drinks of alcohol per day, and occasionally snorted cocaine. He also travelled multiple times to Vietnam and worked as a cabinet maker.
He was septic (temperature 39°C, heart rate 110 bpm and blood pressure 90/70 mmHg) with cellulitis extending from the nose across the right cheek and up to the right eye, including a preseptal orbital cellulitis. Visual acuity and eye movements were normal. The right nasal vestibule was tender and swollen with purulent discharge originating from it and the nasal septum.
Biochemistry revealed an elevated C-reactive protein of 222.7 () and a normal white cell count of (), neutrophils (), and lymphocytes (). Computed tomography (CT) revealed right sinus mucosal thickening and preseptal tissue swelling overlying the right orbit extending over the zygoma and the nose, with no intracranial collection, cavernous sinus thrombosis, orbital collection, or bony erosion (Figures 1 and 2).
The patient underwent endoscopic sinus surgery. A right nasal vestibule and septal abscess were identified with boggy, inflamed nasal mucosa (Figures 3 and 4). Incision and drainage were performed and necrotic tissue debrided, with samples sent for histopathology and culture. Septal cartilage was intact. A right uncinectomy, middle meatal antrostomy and anterior ethmoidectomy were performed. No pus was seen in the sinuses.
Blood cultures and swabs from the nasal cavity revealed a gram-negative bacillus, Burkholderia pseudomallei (sensitive to ceftazidime, cotrimoxazole, and meropenem). The patient spent 5 days in intensive care, requiring ionotropes for ongoing sepsis, and a further 4 days on the ward. He received daily nose toilet, saline sinus rinse, topical nasal decongestants, strict blood sugar control, and initial treatment with intravenous meropenem. Treatment included a further 8 weeks intravenous ceftazidime 2 g qid as a “hospital in the home” patient, followed by 3 months oral Bactrim DS 2 tabs bd with folic acid 5mg daily and doxycycline 100 mg bd.
Melioidosis is caused by Burkholderia pseudomallei, found in the soil and water of endemic regions, particularly Asia and Northern Australia. It is also known as Whitmore’s disease, named after Captain Alfred Whitmore who in 1911 first isolated the bacteria from an opiate addict in Rangoon, Burma .
The annual incidence in the general northern territory population is 19.6 cases per 100 000 population and increases with wet weather .
Transmission of melioidosis is via percutaneous or inhaled routes. The latter was documented during the Vietnam War where American soldiers were reported to have been infected by the aerosol created by helicopters taking off from rice paddies .
Acute melioidosis has an incubation period ranging from 1 to 21 days. Animal-to-human and human-to-human transmissions are rare . Isolation of B. pseudomallei from bodily fluids of patients remains the gold standard in diagnosis.
Melioidosis can present with acute, chronic, or latent infection with reactivation. Pneumonia is the most frequent manifestation, followed by genitourinary infections, skin infections, bacteraemia without evident focus, septic arthritis, osteomyelitis, and encephalomyelitis [5–8].
The acute phase of therapy for melioidosis involves at least 14 days of monotherapy with either ceftazidime, meropenem, or imipenem. Doxycycline with or without trimethoprim-sulfamethoxazole is the mainstay of eradication phase therapy, which lasts at least 3 months .
The overall mortality rate for melioidosis is about 14%, with the mortality from septic shock as high as 86%. 97.4% of the deceased have at least one risk factor .
Our patient was immunosupressed with poorly controlled diabetes, hepatitis B, and alcohol abuse. He was likely originally infected in Vietnam, an endemic area, and had presented a year previously with a necrotising pneumonia diagnosed as melioidosis. However, he failed to comply with treatment and was lost to followup. Reactivation was likely from a pustule or abscess in the nose, leading to extension to surrounding tissues and sepsis.
A single previous case of orbital cellulitis and sinusitis was described in a 42-year-old previously healthy gentleman from Singapore in 1996 .
Melioidosis is a significant opportunistic infection with a high mortality rate in immunocompromised patients. In an age of international travel, surgeons in Australia need to consider melioidosis, especially in a returned traveller from an endemic region.
Conflict of Interests
The authors declare no conflict of interests in this case report.
- A. Whitmore and C. S. Krishnaswami, “An account of the discovery of a hitherto undescribed infective disease occurring among the population of Rangoon,” Indian Medical Gazette, vol. 47, pp. 262–267, 1912.
- B. J. Currie, S. P. Jacups, A. C. Cheng et al., “Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia,” Tropical Medicine and International Health, vol. 9, no. 11, pp. 1167–1174, 2004.
- D. R. Weber, L. E. Douglass, W. G. Brundage, and T. C. Stallkamp, “Acute varieties of melioidosis occurring in U. S. soldiers in Vietnam,” The American Journal of Medicine, vol. 46, no. 2, pp. 234–244, 1969.
- J. B. McCormick, D. J. Sexton, J. G. McMurray, E. Carey, P. Hayes, and R. A. Feldman, “Human to human transmission of Pseudomonas pseudomallei,” Annals of Internal Medicine, vol. 83, no. 4, pp. 512–513, 1975.
- B. J. Currie, L. Ward, and A. C. Cheng, “The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year darwin prospective study,” PLoS Neglected Tropical Diseases, vol. 4, no. 11, article e900, 2010.
- A. C. Cheng and B. J. Currie, “Melioidosis: epidemiology, pathophysiology, and management,” Clinical Microbiology Reviews, vol. 18, no. 2, pp. 383–416, 2005.
- B. J. Currie, D. A. Fisher, D. M. Howard et al., “Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature,” Clinical Infectious Diseases, vol. 31, no. 4, pp. 981–986, 2000.
- D. Dance, “Meliodosis,” Current Opinion in Infectious Diseases, vol. 15, pp. 127–132, 2002.
- Melioidosis, In: eTG complete [Internet], Melbourne, Australia, Therapeutic Guidelines Limited, November 2012, https://auth.athensams.net/?ath_returl=https%3a%2f%2flogin.proxy1.athensams.net%2fathens%3furl%3dezp.2aHR0cDovL29ubGluZS50Zy5vcmcuYXUvaXAv&ath_dspid=ATHENSPROXY.
- P. K. Wong and P. H. Ng, “Melioidosis presenting with orbital cellulitis,” Singapore Medical Journal, vol. 37, no. 2, pp. 220–221, 1996.