Ossifying Parotid Carcinoma ex Pleomorphic Adenoma

Figure 2

CXPA microscopic examination. (a) The benign myxoid component (top) is separated by a thick fibrous band from the malignant component (bottom). The neoplasm is composed of large cells with eosinophilic cytoplasm in a glandular pattern, H&E, 400x. (b) The well-circumscribed and encapsulated tumor shows areas of residual pleomorphic adenoma (lower right). A more cellular area (left) with irregular glandular architecture and composed of large cells with eosinophilic cytoplasm and pleomorphic nuclei is confined within the capsule, H&E, 400x. (c) The neoplasm is surrounded by a thin capsule (top) and cells show remarkable degree of cytological pleomorphism with hyperchromatic nuclei and prominent nucleoli, H&E, 400x. (d) The ossification comes from the periphery of the tumor within the capsule (left) and is present at the periphery of the benign components of the tumor (right), H&E, 100x.

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