Case Report
Concurrent Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx in a Married Couple
Table 1
Published cases of synchronous presentation of human papillomavirus-positive oropharynx squamous cell carcinoma among couples.
| | | Haddad et al. [1] | Andrews et al. [8], Couple #1 | Andrews et al. [8], Couple #2 | This study |
| Partner 1 | Sex | Female | Female | Female | Female | Age | 75 | 58 | 51 | 60 | Smoking history | Had 25 yr smoking history and quit 10 yrs ago | None | None | Current smoker of 25 yrs | Alcohol use | None | None | None | Occasional | Diagnosis | SCC | SCC | SCC | SCC | Primary lesion | Right tonsil | Right tonsil | Left tonsil | Right tonsil | TNM classification | T1 N1 M0 | T1 N2b M0 | T2 N1 M0 | T4b N2c M0 | p16 | p16+ | p16+ | p16+ | p16+ | HPV | HPV16+ | HPV16+ | HPV16+ | HPV16+ | Treatment | Not reported | Chemoradiation | Left neck dissection and postoperative radiation | Chemoradiation |
| Partner 2 | Sex | Male | Male | Male | Male | Age | 75 | 56 | 57 | 60 | Smoking history | Had 12 yr smoking history and quit 25 yrs ago | Had minimal smoking history and quit 38 yrs ago | None | None | Alcohol use | Drank heavily in past and quit 25 yrs ago | None | None | Occasional | Diagnosis | SCC | SCC | SCC | SCC | Primary lesion | Location unknown | Right tonsil | Right tonsil | Left base of tongue | TNM classification | TX N2a M0 | T1 N2a M0 | T2 N2b M0 | T2 N2c M0 | p16 | Not reported | p16+ | p16+ | p16+ | HPV | HPV16+ | HPV16+ | HPV16+ | HPV16+ | Treatment | Not reported | Chemoradiation and neck dissection | Chemoradiation | Transoral robotic tongue base resection, bilateral neck dissection, and chemoradiation |
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SCC: squamous cell carcinoma; HPV: human papillomavirus.
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