Concurrent Human Papillomavirus-Positive Squamous Cell Carcinoma of the Oropharynx in a Married Couple

Table 1

Published cases of synchronous presentation of human papillomavirus-positive oropharynx squamous cell carcinoma among couples.

		Haddad et al. [1]	Andrews et al. [8], Couple #1	Andrews et al. [8], Couple #2	This study
Partner 1	Sex	Female	Female	Female	Female
	Age	75	58	51	60
	Smoking history	Had 25 yr smoking history and quit 10 yrs ago	None	None	Current smoker of 25 yrs
	Alcohol use	None	None	None	Occasional
	Diagnosis	SCC	SCC	SCC	SCC
	Primary lesion	Right tonsil	Right tonsil	Left tonsil	Right tonsil
	TNM classification	T1 N1 M0	T1 N2b M0	T2 N1 M0	T4b N2c M0
	p16	p16+	p16+	p16+	p16+
	HPV	HPV16+	HPV16+	HPV16+	HPV16+
	Treatment	Not reported	Chemoradiation	Left neck dissection and postoperative radiation	Chemoradiation
Partner 2	Sex	Male	Male	Male	Male
	Age	75	56	57	60
	Smoking history	Had 12 yr smoking history and quit 25 yrs ago	Had minimal smoking history and quit 38 yrs ago	None	None
	Alcohol use	Drank heavily in past and quit 25 yrs ago	None	None	Occasional
	Diagnosis	SCC	SCC	SCC	SCC
	Primary lesion	Location unknown	Right tonsil	Right tonsil	Left base of tongue
	TNM classification	TX N2a M0	T1 N2a M0	T2 N2b M0	T2 N2c M0
	p16	Not reported	p16+	p16+	p16+
	HPV	HPV16+	HPV16+	HPV16+	HPV16+
	Treatment	Not reported	Chemoradiation and neck dissection	Chemoradiation	Transoral robotic tongue base resection, bilateral neck dissection, and chemoradiation

SCC: squamous cell carcinoma; HPV: human papillomavirus.