Case Report

Primary Small Cell Carcinoma of the Hypopharynx: A Report of Two Cases and Review of Nine Additional Cases

Table 1

Review of the clinicopathological features of the reported 9 cases and our 2 cases of SmCC of the hypopharynx.

NumberAuthorYearAge/sexSmokingStage (TNM) Main symptomSiteExtent of lesion at presentationHistologyLocoregional TXAdjuvant systemic TXPCIMetastases (observed throughout the course)Follow-up

(1)Ferlito and Polidoro198057/M+T1N2bM0Neck massPSLocoregionalCombined with SCCRadical S + RTNoneCervical nodes, bone, soft tissueDied of cancer 3.5 months after diagnosis
(2)Mills et al.198349/M+NANeck mass, dysphagia, weight lossPSLocoregionalCombined with SCCRadical S + RTNoneCervical nodesAlive free of cancer 6 months after treatment
(3)Baugh et al.198563/FT4a, more than N2c, M0Dysphagia, cervical massPSLocoregionalPure SmCCIncomplete SMany times (more than four)Cervical nodesAlive free of cancer 55 months after diagnosis
(4)Baugh et al.198535/MT3N2aM0Dysphagia, weight lossBase of tonsil to PSLocoregionalPure SmCCRTnoneCervical nodeAlive free of cancer 21 months after diagnosis
(5)Gaba et al.200565/Mex+T4aN1M0Dysphagia, weight lossPSLocoregionalPure SmCCIncomplete S + CRTMany times (more than four)Cervical nodeAlive free of cancer more than 24 months after diagnosis
(6)Sano et al.200567/F+NANeck massPSLocoregionalPure SmCCRTLess than fourCervical node, lung, liverDied of cancer 13 months after diagnosis
(7)Uwa et al.201373/M+T4aN2bM0Neck massPSLocoregionalCombined with SCCRadical SNoneCervical and mediastinum nodes, liver, lungDied of cancer 9 months after treatment
(8)Bayram et al.201550/M+T4aN2bM1 (lung)Severe respiratory distressPSLocoregional-distantPure SmCCIncomplete RTLess than fourCervical and lungAlive free of cancer 15 months after treatment
(9)Misawa et al.201674/M+T2N0M0Throat pain, hoarsenessPSLocalCombined with SCCCRTNoneBoneDied of cancer 7 months after treatment
(10)Nakahira et al.75/M+T2N2cM1 (bone)DysphagiaPSLocoregional-distantCombined with SCCNoneMany times (more than four)Bone, liverDied of cancer 6 months after treatment
(11)Nakahira et al.73/MT3N2bM0DysphagiaPSLocoregionalCombined with SCCRadical S + RTMany times (more than four)+Cervical nodes, lungAlive with cancer 26 months after treatment

TX: therapy, PCI: prophylactic cranial irradiation, NA: not available, PS: pyriform sinus, S: surgery, RT: radiation therapy, and CRT: concurrent chemoradiotherapy.