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Case Reports in Pathology
Volume 2011 (2011), Article ID 252805, 4 pages
http://dx.doi.org/10.1155/2011/252805
Case Report

Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature

1Departments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, Italy
2Department of Urology, Central Hospital, 60035 Jesi, Italy

Received 23 August 2011; Accepted 20 September 2011

Academic Editors: D. Cao and D. Tsuruta

Copyright © 2011 Rosanna Zamparese et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). We describe a case of a 71-year-old man that developed progressive urinary obstruction symptoms and was subjected to a transurethral prostatic resection (TURP). Histologically, there is a diffuse proliferation of epithelioid and spindle cells that showed rare atypical mitotic figures. Immunohistochemically, the neoplastic cells express diffusely CD34 and focally progesterone whereas no immunoreactivity was seen for cytocheratin, desmin, S-100, Bcl-2, chromogranin, CD117, and actin smooth muscle. A final diagnosis of low-grade prostatic stromal sarcoma (LG-PS) was made. This is a really rare neoplasm; in the literature, in fact, to our knowledge, only 6 cases are described and all of these were alive and free of disease at followup. Our patient too is free of disease at 15 months from the diagnosis.