Case Report

Subcutaneous Angiomatoid Fibrous Histiocytoma Mimicking Metastatic Melanoma

Table 1

Overview of all case reports on angiomatoid fibrous histiocytoma between 2002 and 2012.

ArticlePatient ageLocalizationDifferential diagnosisImmunohistochemical stainingMolecular diagnostics

(1) Mansfield et al.,
2010 [12]
M, 25Left axillaMetastatic melanoma, rhabdomyosarcomaPositive: vimentin, EMA, and CD68
Negative: S100, Melan A, HMB45, myogenin, desmin, smooth muscle actin, and keratin
(2) Song et al.,
2011 [13]
F, 23Palatum Necrotizing sialometaplasia, tertiary syphilis, and Wegener’s granulomatosisPositive: proliferating cell nuclear antigen, S-100, CD31, and desmin
Negative: α-smooth muscle actin, p53, survivin, CD68, and TNF-α
(3) Moura et al.,
2011 [4]
M, 80MediastinumPositive: EMA and desmin
Negative: S100, Melan A, smooth muscle actin, anticytokeratin CAM 5.2, anticytokeratin OSCAR, chromogranin, synaptophysin, myogenin, and glial fibrillary acidic protein
EWSR1/CREB1 fusion
(4) Ajlan et al.,
2010 [14]
F, 28
F, 85
Left shoulder
Right upper arm
(5) Cernik et al.,
2009 [15]
M, 6Left forearm HemangiomaNegative: CD34, reticulin, and pancytokeratin
(6) Mangham et al.,
2010 [10]
M, 11Right upper armPositive: desmin, EMA, and cytokeratin (AE1/AE3)
Negative: CD31, CD34, CD45, S100, smooth muscle actin, HMB45, myoD1, myoglobin, myf4, and myogenin
EWSR1-ATF1 fusion
(7) Ochalski et al.,
2010 [11]
M, 35IntracranialMeningiomaPositive: vimentin, desmin, and CD68
Negative: MYOD1, myoglobin, and myogenin
Rearranged ESWR1 gene
(8) Ren et al.,
2009 [16]
M, 46IntrapulmonalPositive: EMA, desmin, CD163, and CD68
Negative: S100 protein, smooth muscle actin, CD34, cytokeratin, anaplastic lymphoma kinase-1, CD21, CD23, and immunoglobulin light chains
EWS/ATF1 gene fusion
(9) Weinreb et al.,
2008 [17]
M, 8Scalp Pleomorphic fibrous histiocytomaPositive: CD99, Factor 3a, desmin, and SMA
Negative: S100, pankeratin
EWSR1 translocation on 22q12
(10) Martelli et al.,
2008 [6]
F, 7 (HIV+)Right kneeBenign epithelial cyst, mesenchymal tumorPositive: desmin
Negative: S100, CD68, and smooth muscle actin
(11) Dunham et al.,
2008 [18]
M, 25Intracranial Positive: v imentin, CD68, S100, CD31, and desmin
Negative: CD34, glial fibrillary acidic protein, neurofilament, synaptophysin, CAM 5.2, HMB-45, and progesterone receptor stains
EWS/ATF-1 gene fusion
(12) Koletsa et al.,
2007 [19]
F, 28Left legPositive: vimentin, CD68
Negative: SMA, desmin, CD34, CD31, factor VIII-related antigen, S-100, EMA, and cytokeratins cam5.2, AE1/AE3 and 17
(13) Hallor et al.,
2007 [20]
M, 11
M, 10
Paravertebral
Right clavicular region
EWSR1-ATF1 fusion genes (2x)
(14) Pratibha and Ahmed, 2006 [21]F, 13Left lower jawPositive: CD68
Negative: desmin and keratin
(15) Lai et al.,
2006 [22]
F, 28Neck
(16) Hallor et al.,
2005 [23]
M, 9Right elbowReticulum cell tumor,
Rosai-Dorfman disease
Positive: CD68, vimentin
Negative: S100, CD1a, cytokeratin, EMA, CD21, CD31, CD34, HMB45, and Melan A
EWSR1-ATF1 fusion gene
(17) Hothi et al.,
2004 [24]
M, 13Left thigh
(18) Raddaoui et al.,
2002 [25]
M, 38Right upper armHigh-grade sarcomaPositive: vimentin, calponin, CD99, and desmin
Negative: keratin AE-1/AE-3, S100, CD34, CD57, macrophage specific marker, MSA, and SMA
FUS/ATF1 fusion gene