Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

Table 2

A review of performed immunohistochemical examinations in CCOT and GCOC in the literature.

	Zhu et al. (2012) [19]	Li et al. (2011) [12]	Gong et al. (2009, 2006) [20, 21]	Motosugi et al. (2009) [4]	Roh et al. (2008) [13]	Geng et al. (2008) [22]	Kim et al. 2000 [23]	Folpe et al. (1998) [24]	Piattelli et al. (1998) [25]
CCOT
Ki-67	W	W	W	W					S
P53				W					W
CK5 & CK14		P
CK18		N
TIMP-1						W
MMP-9	W in T; W in St; W in G		W in T; W in St			W
NF-kappaB			S in CT; W in NT
BCL2									S
GCOC
Ki-67	S	S	S	S
P53				S				P
CK5 & CK14		P
EMA & NSE								P
CK18		N
TIMP-1						S
MMP-9	W in T; S in St; W in G		W in T; S in St			S
TRAP & VR					N in T; P in G
INVOLUCRN; CK, BCLXL							P in T; N in G
BCL2							N in T; N in G
BAX							N in T; P in G

MMP: matrix metalloproteinase
TIMP: tissue inhibitor of metalloproteinase
VR: vitronectin receptor
TRAP: tartrate-resistant acid phosphatase
T: tumor
St: stroma
G: ghost cell
P: positive
N: negative
W: weak
S: strong
CT: cytoplasm of tumor cells
NT: nucleus of tumor cells.