|
Investigators | Markers | Immunohistochemical reactivity |
|
Fulciniti et al. (2010) [9] | Collagen IV | Enhanced lobular architecture |
Cytokeratin 14 | Enhanced the ratio of apocrine cells present in the epithelial lining of lobular structures |
Gross cystic disease fluid protein (GCFDP) | Sebaceous cells |
|
Gurgel et al. (2010) [8] | Ki-67 | Positive in less than 1% of cells |
CKAE1/AE3, EMA, GCDFP-15 | Tubuloacinar elements |
Estrogen, progesterone, and CK 34βE12 | Negative |
SMA, S100 | Myoepithelial layer |
|
Swelam (2010) [5] | S100 | Lesional ductal and spindle-shaped cells |
Bcl-2 | Strong, diffuse cytoplasmic immunoreactivity in basal cells of neoplastic cells |
Ki-67 | Sporadic positivity in Basal cells of neoplastic ductal epithelium |
EBV | Expression in neoplastic S100 positive cells |
HPV-1 | Negative |
|
Meer and Altini (2008) [2] | P63 | Peripheral layer of cells surrounding acini, ducts, and cystic spaces outlining these structures |
AE1/AE3 | In ductal lining cells of tubuloacinar elements |
S100 | Ductal cells and spindled myoepithelial cells |
AE1/AE3, CAM5.2, EMA, antimicrobial antibody, BRST-2, S100 | Luminal cells |
|
Bharadwaj et al. (2007) [10] | Cytokeratin | In ductal and acinar elements |
SMA, S100 | Myoepithelial layer |
|
Skálová et al. (2006) [4] | CKAE1/AE3 | Positive in ductal and acinar cells |
EMA, S100, antimitochondrial antibody | Variably positive |
CEA, p53, and HER-2/neu | Negative |
GCDFP-15 | Acinar cells with coarse eosinophilic cytoplasm |
Progesterone receptors | Positive in 15% to 20% of epithelial cells |
Estrogen receptors | At least focally in 5% of ductal cells in dysplastic and hyperplastic foci |
SMA, P63, and calponin | Myoepithelial layer |
|
Gnepp et al. (2006) [7] | Calponin, SMA, muscle specific actin, S100 | Myoepithelial layer |
|