Sclerosing Polycystic Adenosis of the Retromolar Pad Area: A Case Report

Table 1

A review of immunohistochemical investigations in SPA cases.

Investigators	Markers	Immunohistochemical reactivity
Fulciniti et al. (2010) [9]	Collagen IV	Enhanced lobular architecture
	Cytokeratin 14	Enhanced the ratio of apocrine cells present in the epithelial lining of lobular structures
	Gross cystic disease fluid protein (GCFDP)	Sebaceous cells
Gurgel et al. (2010) [8]	Ki-67	Positive in less than 1% of cells
	CKAE1/AE3, EMA, GCDFP-15	Tubuloacinar elements
	Estrogen, progesterone, and CK 34βE12	Negative
	SMA, S100	Myoepithelial layer
Swelam (2010) [5]	S100	Lesional ductal and spindle-shaped cells
	Bcl-2	Strong, diffuse cytoplasmic immunoreactivity in basal cells of neoplastic cells
	Ki-67	Sporadic positivity in Basal cells of neoplastic ductal epithelium
	EBV	Expression in neoplastic S100 positive cells
	HPV-1	Negative
Meer and Altini (2008) [2]	P63	Peripheral layer of cells surrounding acini, ducts, and cystic spaces outlining these structures
	AE1/AE3	In ductal lining cells of tubuloacinar elements
	S100	Ductal cells and spindled myoepithelial cells
	AE1/AE3, CAM5.2, EMA, antimicrobial antibody, BRST-2, S100	Luminal cells
Bharadwaj et al. (2007) [10]	Cytokeratin	In ductal and acinar elements
	SMA, S100	Myoepithelial layer
Skálová et al. (2006) [4]	CKAE1/AE3	Positive in ductal and acinar cells
	EMA, S100, antimitochondrial antibody	Variably positive
	CEA, p53, and HER-2/neu	Negative
	GCDFP-15	Acinar cells with coarse eosinophilic cytoplasm
	Progesterone receptors	Positive in 15% to 20% of epithelial cells
	Estrogen receptors	At least focally in 5% of ductal cells in dysplastic and hyperplastic foci
	SMA, P63, and calponin	Myoepithelial layer
Gnepp et al. (2006) [7]	Calponin, SMA, muscle specific actin, S100	Myoepithelial layer