Metastasis of Malignant Melanoma to Urinary Bladder: A Case Report and Review of the Literature

Table 1

Cases of malignant melanoma metastatic to urinary bladder previously reported in the English literature.

Author	Year	Age	Sex	Presenting symptom	Primary	Synchronous metastases	Treatment
Weston and Smith [10]	1964	69	M	Urinary retention	Right lower eyelid	Widespread	None
Bartone [18]	1964	70	F	Hematuria	Left thumb	Lymph nodes, brain	Partial cystectomy
Amar [19]	1964	33	M	Hematuria	Maxillary	Anterior neck	Partial cystectomy
Meyer [9]	1974	69	M	None	Unknown	Widespread	Chemotherapy
Meyer [9]	1974	60	F	Hematuria	Skin, left arm	Unknown	Surgery
Meyer [9]	1974	42	M	Incidental	Skin, right upper back	Widespread	TURBT
Silverstein et al. [20]	1974	56	M	Hematuria	Axillary lymph nodes	Absent	BCG
Tolley et al. [21]	1975	48	F	Hematuria	Vulva	Absent	Radical cystectomy
Stein and Kendall [22]	1984	50	M	Hematuria	Left arm	Absent	TURBT + chemotherapy
Irisawa et al. [23]	1987	77	M	Occult blood	Eye	Diffuse	TURBT
Arapantoni-Dadioti et al. [24]	1995	28	F	Dysuria	Axillary lymph node	Skin (abdomen, limbs), lung, and brain	TURBT
Demirkesen et al. [25]	2000	45	F	Frequency, hematuria	Right heel	Widespread	Chemotherapy
López et al. [26]	2002	75	M	Hematuria, lower urinary symptoms	Skin, scapula	Unknown	Cystectomy
Lee et al. [27]	2003	46	M	Hematuria	Skin, back	Lungs, liver, and mesenteric lymph nodes	Removed tumor and then IL-2 therapy
Fink et al. [28]	2003	38	M	Hematuria	Skin, left upper leg	Tonsils, cervical lymph nodes, esophagus, stomach, and skin	Embolization of nutrient vessels
Maeda et al. [29]	2008	65	M	Hematuria, urinary obstruction	Skin, foot	Unknown	TURBT
Nohara et al. [30]	2009	62	M	Hematuria	Skin, breast	Lymph nodes	Unknown
Efesoy and Cayan [4]	2011	60	F	Hematuria, weight loss	Skin, right middle finger	Brain, lung, and retroperitoneal and pelvic lymph nodes	TURBT
Nair et al. [6]	2011	54	M	Hematuria	Conjunctiva	Widespread	TURBT, chemo, and radiation for brain metastases
Charfi et al. [31]	2012	54	M	Unknown	Esophagus	Lumbar lymph nodes	Unknown
Paterson et al. [3]	2012	84	M	Rectal bleeding	Skin, upper back	Lungs
Ikeda et al. [32]	2013	54	F	Hematuria	Skin, leg	Absent	TURBT
Rishi et al. [5]	2014	61	F	Dysuria, hematuria	Skin, mid-back	Brain, lung, and skin	Tumor resection, brain radiotherapy, and temozolomide
Meunier (current case)	2014	55	F	Hematuria	Skin, thigh	Liver, spleen, and lung	Ipilimumab + anti-PD-1 immunotherapy trial