Vancomycin Hypersensitivity Diagnosed by Lymphocyte Blast Transformation

Figure 1

Secreted fraction of INF-γ production by the patient’s peripheral lymphocytes after 18 h stimulation with various concentrations of Vancomycin and Metronidazole. The patient did not produce any detectable levels of INF-γ with Ceftriaxone, Amoxicillin, and Meropenem stimulation at all drug concentrations (<0.16 IU/mL). Likewise, the levels of INF-γ production in Vancomycin-naïve control subject were below the threshold of detection (<0.16 IU/mL) at all Vancomycin concentrations.