Case Reports in Pediatrics / 2012 / Article / Tab 1 / Case Report
Chronic Granulomatous Herpes Encephalitis in a Child with Clinically Intractable Epilepsy Table 1 Histologically verified cases of chronic granulomatous herpes simplex encephalitis.
Source Latency Presentation Treatment Course Jay et al. [6 ] (Pt. 2) 2.5 years Intractable Seizures Temporal lobectomy Not available Love et al. [4 ] (Pt. 1) 4.5 years Intractable Seizures Hemispherectomy Marked Improvement Love et al. [4 ] (Pt. 2) 10 years Intractable Seizures Temporal lobe excision × 2 + Acyclovir Marked Improvement Love et al. [4 ] (Pt. 3) 2 months Congenital HSV2 Skin infection* Topical Acyclovir Sudden death Adamo et al. [7 ] 14 years Intractable Seizures Biopsy + Acyclovir Marked Improvement Current case 10 years Intractable Seizures Frontal lobectomy + Acyclovir Minimal improvement
* All cases had documentation of HSV1 infection except Patient 3 from Love et al. [4 ] who had congenital HSV2 infection eventuating in sudden death, with granulomatous herpes encephalitis diagnosed at autopsy.