Septicemia in a Neonate following Therapeutic Hypothermia: The Literature Review of Evidence

Table 1

Publications of therapeutic hypothermia reviewed.

	Population	Study type	Reason for hypothermia	Remarks
Hall et al., 2010 [10]	26–30 weeks	Nonrandomized controlled trial	Necrotizing enterocolitis	Neutrophil count measured
Adelson et al., 2005 [11]	0–13 years	Randomized controlled trial	Traumatic brain injury	Children also recruited
Adelson et al., 2005 [11]	0–17 years	Randomized controlled trial	Traumatic brain injury	Children and adolescence also recruited
Eicher et al., 2005 [2]	≥35 weeks	Randomized controlled trial	Neonatal encephalopathy	Neutrophil counts measured; infection stratified according to site (UTI, pneumonia, and sepsis)
Gluckman, 2005 [12]	≥37 weeks	Randomized controlled trial	Neonatal encephalopathy	Large scale trial (𝑛>200)
Shankaran, 2005 [13]	≥36 weeks	Randomized controlled trial	Hypoxic ischemic encephalopathy	Large scale trial (𝑛>200); septicemia measured
Akisu et al., 2003 [14]	≥37 weeks	Randomized controlled trial	Perinatal asphyxia	Location of infection not specified
Gunn et al., 1998 [15]	≥37 weeks	Randomized controlled trial	Perinatal asphyxia	No infection reported in hypothermic group
Clardy et al., 1985 [9]	Pediatric	Case-control trial	Hypoxic ischemic encephalopathy	Neutrophil studies performed