Asparaginase-Induced Hypertriglyceridemia Presenting as Pseudohyponatremia during Leukemia Treatment

Table 3

Case reports in the English literature of asparaginase-induced hypertriglyceridemia.

Age	Sex	Disease	Phase of therapy	Lipid level	Complications	Treatment	Resolution	Ref
9	F	T cell ALL	N/a	N/a	Sagittal sinus thrombosis, transient diabetes mellitus	N/a	N/a	[12]
10	F	Pre-B-cell ALL	Consolidation II	Trig: 20,600 mg/dL; Chol: 1640 mg/dL	Lipemia retinalis, moderate transaminasemia	Heparinized	Returned to nml 2 weeks after completion of asp treatment	[11]
10	F	Pre-B-cell ALL	Induction	Trig: 1817 mg/dL; Chol: 1116 mg/dL	Weakness in lower extremities, lethargy c/w hyperlipidemia-associated hyperviscosity syndrome, moderate transaminasemia	Initiation of gemfibrozil and omega-3 marine oil	Improvement in lipid levels and liver function tests with lipid-lowering drugs	[18]
10	M	T cell ALL	Induction	Trig: 4040 mg/dL; Chol: 540 mg/dL	Acute pancreatitis	Plasmapheresis, removal of asp from treatment plan, low fat diet	Nml within 15 days	[17]
10	F	Pre-B-cell ALL	Maintenance	Trig: 2700 mg/dL; Chol: 1135 mg/dL	Lipemia retinalis	Heparinized	Nml	[13]
13	F	Pre-B-cell ALL	Induction	Trig: 103 mmol/L; Chol: 7.6 mmol/L	N/a	N/a	N/a	[8]
16	F	Pre-B-cell ALL	Induction	Trig: 8510 mg/dL; Chol: 660 mg/dL	Lipemia retinalis, moderate transaminasemia, lethargy, anginal pain, dyspnea	Plasmapheresis, heparinized, acipimox/olbetam antilipidemic	Rapid nml	[15]
17	F	Pre-B-cell ALL	Reinduction	Trig: 5250 mg/dL; Chol: 672 mg/dL	Mild abdominal pain	Conservative management	Nml within 3 weeks	[16]
18	M	ALL	End of Consolidation I	Trig: 1742 mg/dL	Acute pancreatitis	Conservative management	Nml within 2 weeks	[14]

F: female; M: male; Trig: triglycerides; Chol: cholesterol; C/w: consistent with; Nml: normal; Asp: asparaginase; N/a: not available.