A Case of Idiopathic Hypereosinophilic Syndrome Causing Mitral Valve Papillary Muscle Rupture

Table 1

Infectious
HIV Ag/Ab	Nonreactive
Hepatitis A, hepatitis B, and hepatitis C	Nonreactive
Bartonella henselae PCR	Negative
Toxocara	Negative
Strongyloides	Negative
Tropheryma whipplei PCR	Negative
Blood/fungus cultures	Negative
Urine cultures	Negative
Immunologic
ANA (blood and abdominal fluid)	Negative
DSDNA/SSA Ab	Negative
Smith/RNP Ab	Negative
ANCA	Negative
C3	39 mg/dL
C4	2 mg/dL
IgG	345 mg/dL
IgA	111 mg/dL
IgM	143 mg/dL
IgE	191 kU/L
CD4 helper cells	34.3%
CD8 suppressor cells	26.4%
Total CD3	66.2%
Total B-cells	28.9%
Natural killer cells	3.2%
CD4/CD8 ratio	1.3
T-cell interpretation	Normal total B-cells; (CD19)
Other
Beta hCG (urine)	Negative
Cortisol	13.4 μg/dL
Tryptase	2.6 μg/L
Genetic analysis
PDGFRa (4q12) FISH	Normal
PDGFRb (5q33) FISH	Normal
FGFR1 (8p11) FISH	Normal
BCR/ABL1/ASS1 t(9,22) FISH	Normal
KIT (c-KIT) mutation	Not detected
Next-Gen Sequencing myeloid disorders profile; (NeoTYPE analysis)	No evidence of mutation in any of genes tested. Low probability of myeloid neoplasm diagnosis (<10%)

Myeloid disorders profile: ABL1, ASXL1, ATRX, BCOR, BCORL1, BRAF, CALR, CBL, CBLB, CBLC, CDKN 2A, CEBPA, CSF3R, CUX1, DNMT3a, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, IKZF1, JAK2 Exon 12 + 14, JAK3, KDM6A, KIT, KRAS, MLL, MPL, MYD 88, NOTCH 1, NPM1, NRAS, PDGFRA, PHF 6, PTEN, PTPN11, RAD21, RUNX1, SETBP1, SF3B1, SMC1A, SMC3, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, and ZRSR2.