High-Risk Neuroblastoma with Metastases to Bilateral Kidneys at Diagnosis

Figure 2

Histological findings of the primary tumor and a residual mass in the left kidney. In the primary tumor, H&E staining demonstrated neuroblastoma cell clusters (a), and these cells were immunohistochemically positive for (c) synaptophysin, (e) chromogranin A, and (g) CD56. In the left kidney, it was difficult to identify the metastatic lesion due to chemotherapy (b); however, immunohistochemistry revealed the individually scattered neuroblastoma cells (d–h). Note that color reaction was performed using new fuchsin (red), and brown pigments were hemosiderin or ceroid.

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