Improvement in Impaired Social Cognition but Not Seizures by Everolimus in a Child with Tuberous Sclerosis-Associated Autism through Increased Serum Antioxidant Proteins and Oxidant/Antioxidant Status
Table 1
Clinical characteristics of the case.
Age
Female, 8 years
Age at onset of ASD
6 years
MRI or echo
(i) AML on bilateral kidneys
(ii) SEN left on the anterior horn of lateral ventricle
ASD features
(i) Impaired communication
(ii) Wrapping up doll play with repeated finger-sucking.
ADI-R score
ADI-R
Reciprocal interaction: 21
Communication: 19
Repetitive behaviors: 13
Total scores of SRS and ABC
SRS: 50
ABC: 107
WISC IQ
67
Everolimus doses
2.5 mg/day for 24 weeks
Results
ABC score: 50% decrease
SRS score: 26% decrease
Social response and repetitive behaviors were improved
Serum levels of Tf and Cp
Serum Cp and Tf levels increased from baseline to 24 weeks of treatment in accordance with symptom improvement
Serum levels of TP, ox-LDL, and creatine
Serum TAP levels showed trend toward opposite decreased ABC scores
Serum creatine levels showed no definite alteration
