Long-Term Remission of a Spinal Atypical Teratoid Rhabdoid Tumor in Response to Intensive Multimodal Therapy

Figure 1

(a) Initial CT scan which shows 2.8 cm right suprarenal hypodense mass, extending to the spinal canal (T9–T12) and cause spinal cord compression (yellow arrow). (b) Histology of the tumor is composed of large pleomorphic cells with prominent nucleoli and clear nearly vacuolated cytoplasm (inset); background of scattered acute inflammatory cells are seen (Hematoxylin and eosin (H&E) stain; 40x). (c) Tumor cells containing more abundant eosinophilic cytoplasm, with focal myxoid changes (inset) (Hematoxylin and eosin (H&E) stain; 10x). (d) Tumor cells are diffusely positive for SMA (20x). (e) Focal tumor reactivity for EMA is seen (20x). (f) Complete loss of tumor cells’ immunoreactivity for SMARCB1/INI1, with maintained internal control in lymphocytes between tumor cells (red arrow) (20x).

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