Neonatal Chylothoraces: A 10-Year Experience in a Tertiary Neonatal Referral Centre

Table 2

Case series of neonatal chylothorax.

Author and year	Number of neonates	Ventilation (days)	Number given MCT feeds	Number treated with octreotide and dose	Octreotide duration (days)	Octreotide efficacy	Pleurodesis or thoracic duct ligation
Altuncu et al. (2007) [5]	3	N/R	n = 3	n = 1 (1–10 mcg/kg/hr)	28	No response	n = 1
Matsukuma et al. (2009) [6]	2	N/R	n = 2	n = 2 (0.5–10 mcg/kg/hr)	16–20	No response	n = 2
Bellini et al. (2012) [7]	30	30	n = 28	n = 6 (1–10 mcg/kg/hr)	8–38	Decreased chylous production, but not quantified	n = 1
Horvers et al. (2012) [8]	7	16	n = 7	n = 7 (2–12 mcg/kg/hr)	Median 22 (11–46)	Possible response in two neonates	n = 0
Shah and Sinn (2012) [9]	6	30	n = 6	n = 6 (0.5–10 mcg/kg/hr)	Median 20 (4–41)	Resolution in five neonates	n = 0
Downie et al. (2013) [1]	10	8	n = 7	n = 3 (3.5–10 mcg/kg/hr)	N/R	Response in two neonates: not quantified	n = 0
Landis et al. (2013) [10]	11	11	N/R	n = 6 (1–13 mcg/kg/hr)	N/R	No response	n = 0
Bialkowski et al. (2015) [2]	28	23	n = 25	n = 7 (3–10 mcg/kg/hr)	Median 21 (10–45)	No response	n = 0
Hua et al. (2016) [11]	4	1	N/R	n = 3 (N/A)	14	No response	n = 4
Yin et al. (2017) [12]	14	13	n = 12	n = 3 (1–6 mcg/kg/hr)	Median 6	Average drain output significantly lower: three days after treatment. Median 62 ml versus 133 ml ()	n = 0
Shillitoe et al. (2018) [13]	21	N/R	n = 2	n = 1 (maximum dose 10 mcg/kg/hr)	N/R	On the maximum dose there was a 50% reduction in five days	n = 0
Zaki et al. (2018) [14]	9	N/R	n = 9	n = 9 (1–10 mcg/kg/hr)	5–66	Resolution in three neonates: not quantified	n = 0

N/R: not reported.