Case Series
COVID-19 Symptomatic Newborns with Possible Postpartum Transmission of SARS-CoV-2
Table 1
Demographic and characteristic data of neonates infected with COVID-19.
| | Demographic data | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | Case 8 | Case 9 | Case 10 |
| | Gestational age | 37 w | 39 w | 30 w | 37 w | 37 w | 39 w | 39 w | 40 w | 30 w | 37 w |
| | Gender | Male | Female | Female | Male | Female | Male | Male | Female | Male | Male |
| | Type of birth | C/S | NVD | C/S | C/S | NVD | NVD | NVD | NVD | C/S | NVD |
| | Birth weight (g) | 3900 | 2600 | 1280 | 2200 | 3200 | 2000 | 3100 | 3200 | 1600 | 2000 |
| | APGAR scores at 1 and 5 min | (8–9) | (8–9) | (2–6) | (8–9) | (9–10) | (9–10) | (9–10) | (9–10) | (5–8) | (8–9) |
| | Concomitant disorders | VSD | − | PDA | Hydrocephaly | − | − | − | − | − | − |
| | Postnatal age at admission, day | 21 d | 10 d | At birth | 15 d | 18 d | 3 d | 11 d | 15 d | 15 d | 8 d |
| | Length stay, day | 8 d | 4 d | 21 d | 10 d | 4 d | 6 d | 7 d | 6 d | 11 d | 10 d |
| | Positive maternal history of COVID-19 | − | − | + | − | − | − | − | − | − | − |
| | Positive family history of COVID-19 | + | + | + | − | + | − | + | + | − | − |
| | Clinical manifestation |
| | Temperature | 38.3 | 36.6 | 36.7 | 38.1 | 37.9 | 36.9 | 38.7 | 38 | 36 | 38.5 |
| | Respiratory distress (tachypnea, grunting, nasal flaring) | + | + | + | + | + | + | − | − | + | + |
| | GI symptoms | − | − | − | − | − | − | − | − | − | − |
| | Drooling | + | − | − | + | + | + | − | − | + | − |
| | Seizure | − | − | − | − | − | − | − | − | − | − |
| | Laboratory findings |
| | WBC (×1000/mm3) | 7.1 | 6 | 11.8 | 12.3 | 12.5 | 13.9 | 14.7 | 2.1 | NA | 11.1 |
| | ALC (%) | 34 | 46.6 | 42.8 | 18.8 | 59.6 | 27.6 | 47.3 | 25.2 | NA | 38.8 |
| | ALC (cells/mm3) | 2414 | 2796 | 5050 | 2312 | 7450 | 3836 | 6953 | 529 | NA | 4307 |
| | Absolute PMN count (%) | 60 | 44.3 | 48.8 | 72.8 | − | − | − | 51.5 | − | 56 |
| | PLT (×1000/mm3) | 194 | 111 | 337 | 143 | 323 | 53 | 330 | 238 | NA | 73 |
| | CRP (mg/L) | 5 | 5 | 96 | 8 | 95 | 5 | 96 | 5 | 5 | 7 |
| | LDH (IU/L) | 879 | 630 | 972 | 442 | 771 | 999 | 613 | NA | 564 | 953 |
| | Blood group | B+ | O+ | O+ | NA | A+ | A+ | O+ | NA | O- | B- |
| | Imaging |
| | CXR | Over inflammation + stomach dilation | NL | NL | NL | NL | NL | NL | NL | NL | NL |
| | Brain sonography | NL | NL | NL | Ventriculomegaly | NL | NL | NL | NL | NL | NL |
| | Cardiovascular | Large VSD | NL | PDA | Large ASD + large VSD + PH | Large PFO + ASD + MI LD TR | NL | NL | NL | NL | NL |
| | Respiratory support |
| | Surfactant treatment | + | − | + | − | − | − | − | − | + | − |
| | Mechanical ventilation | + | + | + | − | − | + | − | − | − | − |
| | nCPAP | − | − | − | − | − | − | − | − | + | + |
| | Oxygen hood | − | − | − | + | + | − | − | + | − | − |
| | No respiratory support | − | − | − | − | − | + | − | − | − | − |
| | Outcomes of the neonates |
| | Dead | + | + | − | − | − | + | − | − | − | − |
| | Alive | − | − | + | + | + | − | + | + | + | + |
| | Outcomes of the mother |
| | Dead | − | − | + | − | − | − | − | − | − | − |
| | Alive | + | + | − | + | + | + | + | + | + | + |
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