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Case Reports in Psychiatry
Volume 2013 (2013), Article ID 697872, 3 pages
http://dx.doi.org/10.1155/2013/697872
Case Report

Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers

1ST4 in General Adult Psychiatry, Bracton Centre, Oxleas NHS Foundation Trust, Dartford, Kent DA2 7AF, UK
2South West London and St. George's Mental Health NHS Trust, Springfield University Hospital, 61 Glenburnie Road Tooting, London SW17 7DJ, UK
3South London and Maudsley NHS Foundation Trust, Maudsley Hospital, Denmark Hill, London SE5 8AZ, UK

Received 26 August 2013; Accepted 17 September 2013

Academic Editors: J. S. Brar and F. Oyebode

Copyright © 2013 Shahzad M. Alikhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. H. Miller, V. Maletic, and C. L. Raison, “Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression,” Biological Psychiatry, vol. 65, no. 9, pp. 732–741, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. T. G. Dinan, “Inflammatory markers in depression,” Current Opinion in Psychiatry, vol. 22, no. 1, pp. 32–36, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. B. Howren, D. M. Lamkin, and J. Suls, “Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis,” Psychosomatic Medicine, vol. 71, no. 2, pp. 171–186, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Dantzer, L. Capuron, M. R. Irwin et al., “Identification and treatment of symptoms associated with inflammation in medically ill patients,” Psychoneuroendocrinology, vol. 33, no. 1, pp. 18–29, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. de Berardis, C. M. V. Conti, N. Serroni et al., “The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature,” International Journal of Immunopathology and Pharmacology, vol. 23, no. 2, pp. 417–422, 2010. View at Scopus
  6. N. Chavda, N. D. Kantharia, and Jaykaran, “Effects of fluoxetine and escitalopram on C-reactive protein in patients of depression,” Journal of Pharmacology and Pharmacotherapeutics, vol. 2, no. 1, pp. 11–16, 2011.
  7. D. M. Tulner, O. R. F. Smith, A. Schins et al., “Antidepressive effect of mirtazapine in post-myocardial infarction depression is associated with soluble TNF-R1 increase: data from the MIND-IT,” Neuropsychobiology, vol. 63, no. 3, pp. 169–176, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Zhu, X. Wei, J. Liu, Y. Hu, and J. Xu, “Interaction of glia activation and neurotransmission in hippocampus of neuropathic rats treated with mirtazapine,” Experimental and Clinical Psychopharmacology, vol. 17, no. 3, pp. 198–203, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. O'Brien, L. V. Scott, and T. G. Dinan, “Antidepressant therapy and C-reactive protein levels,” British Journal of Psychiatry, vol. 188, pp. 449–452, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Hannestad, N. Dellagioia, and M. Bloch, “The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis,” Neuropsychopharmacology, vol. 36, no. 12, pp. 2452–2459, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. W. K. Lagrand, C. A. Visser, W. T. Hermens et al., “C-reactive protein as a cardiovascular risk factor more than an epiphenomenon?” Circulation, vol. 100, no. 1, pp. 96–102, 1999. View at Scopus
  12. R. Sharma, M. Rauchhaus, P. P. Ponikowski et al., “The relationship of the erythrocyte sedimentation rate to inflammatory cytokines and survival in patients with chronic heart failure treated with angiotensin-converting enzyme inhibitors,” Journal of the American College of Cardiology, vol. 36, no. 2, pp. 523–528, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Krishnadas and J. Cavanagh, “Depression: an inflammatory illness?” Journal of Neurology, Neurosurgery and Psychiatry, vol. 83, no. 5, pp. 495–502, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. Z. Rogóz, G. Skuza, and B. Legutko, “Repeated treatment with mirtazapine induces brain-derived neurotrophic factor gene expression in rats,” Journal of Physiology and Pharmacology, vol. 56, no. 4, pp. 661–671, 2005. View at Scopus