Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Table 1

Neurologic complications of tacrolimus therapy in transplants patients (1, 2, 3).

Common side effects (up to 60%)	Mild neurotoxic effects (headache, paresthesias, tremor, sleep disturbances, photophobia, and dysesthesias)
Uncommon side effects (5–8%)	Severe neurologic symptoms (confusion, seizures, posterior reversible encephalopathy, akinetic mutism, and dysarthria)
Rare side effects (0.4–5.2%)	Psychosis, coma, aphasia, and intracranial haemorrhage