Three Patients Needing High Doses of Valproic Acid to Get Therapeutic Concentrations

Table 1

Explaining VPA C/D ratio use with VPA concentrations from a published case [29].

Formulation	VPA dose (mg/day)	Concentration (g/mL)	C/D ratio	C/D ratio × 1000
ECDVNa	1000	112	0.112	112
ECDVNa	750	87	0.116	116
ECDVNa	500	66	0.132	132
ECDVNa	500	64	0.128	128

C/D: concentration-to-dose; ECDVNa: divalproex sodium enterocoated; VPA: valproic acid.