A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab

Table 3

Diagnostic criteria of eosinophilic otitis media.

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(i) Major: otitis media with effusion or chronic otitis media with eosinophil-dominant effusion

(ii) Minor

  (1) Highly viscous middle ear effusion

  (2) Resistance to conventional treatment for otitis media

  (3) Association with bronchial asthma

  (4) Association with nasal polyposis

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Definitive case: major + two or more minor criteria.
Exclusion criteria: Churg-Strauss Syndrome and hypereosinophilic syndrome.