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Case Reports in Pulmonology
Volume 2012 (2012), Article ID 430141, 3 pages
http://dx.doi.org/10.1155/2012/430141
Case Report

Bortezomib-Induced Bronchiolitis Obliterans Organizing Pneumonia

1Medical-Surgical Intensive Care Unit, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, France
2Department of Pulmonology, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, France
3Department of Pathology, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, France

Received 26 July 2012; Accepted 27 September 2012

Academic Editors: G. Hillerdal, M. Takao, and K. Watanabe

Copyright © 2012 E. Vandeix et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS). A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions. Systemic corticotherapy led to a rapid improvement in the patient’s condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.