About this Journal Submit a Manuscript Table of Contents
Case Reports in Pulmonology
Volume 2013 (2013), Article ID 342096, 4 pages
http://dx.doi.org/10.1155/2013/342096
Case Report

An Unusual Cause of Precordial Chest Pain

1Department of Pulmonary Medicine, Samsun Medical Park Hospital, Samsun, Turkey
2Department of Pulmonary Medicine, Faculty of Medicine, Rize University, Rize, Turkey
3Department of Thoracic Surgeon, Samsun Chest Diseases and Thoracic Surgery Hospital, Samsun, Turkey
4Samsun Pathology and Cytology Centre, Samsun, Turkey
5Department of Pulmonary Medicine, Faculty of Medicine, Ondokuz Mayis University, Atakum, Samsun, Turkey

Received 9 September 2012; Accepted 1 October 2012

Academic Editors: S. A. McGrath-Morrow and M. Plataki

Copyright © 2013 Sevket Ozkaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Extraskeletal chondrosarcoma in anterior mediastinum is very rare. A 45-year-old male patient was admitted to the hospital with precordial chest pain. A large and well-shaped mass in the anterior mediastinum was seen radiologically, and there was a clearly compression of the heart by the mass. The lesion was totally resected, and extraskeletal mediastinal chondrosarcoma was histopathologically diagnosed. We aimed to present and discuss the radiologic, clinic, and histopathologic features of unusual presentation of extraskeletal chondrosarcoma in a case.

1. Background

Chondrosarcoma is a malignant mesenchymal tumor arising from cartilage-forming tissues involving the bones (bone chondrosarcoma) or the soft tissues (extraskeletal chondrosarcoma). Bone chondrosarcoma usually affects middle-aged to elderly adults, and the pelvic bones, ribs, shoulder girdle, and long bones are the most common locations. Extraskeletal chondrosarcoma usually affects the deep soft tissues of the extremities and the region of head and neck [1, 2]. Extraskeletal chondrosarcoma in anterior mediastinum is very rare. We present a patient with extraskeletal chondrosarcoma in anterior mediastinum, which was located on the heart.

2. Case Presentation

A 45-year-old, nonsmoker male was admitted to the hospital with precordial chest pain. Blood tests results were normal. Chest roentgenogram was initially thought to be normal. But a masslike opacity was seen on the heart (Figure 1). Thorax computed tomography (CT) and magnetic resonance (MR) imaging demonstrated a large and well-shaped mass in the anterior mediastinum and clearly compression of the heart by the mass (Figure 2).

342096.fig.001
Figure 1: Posteroanterior and lateral chest radiography showing a shadow which superimposed on the shadow of his heart.
342096.fig.002
Figure 2: Thorax CT and MRI showing the large, encapsulated, well-defined anterior mediastinal mass lesion. The mass lesion was obviously compressing the heart.

Pulmonary function tests revealed normal spirometric values. The fiberoptic bronchoscopy was performed, and it was normal. Whole-body PET-CT with low-dose CT protocol was performed before the surgery, and there was no F18-fluorodeoxyglucose (FDG) uptake in lesion or any part of body. The surgical excision was planned. There was no relationship between the mass and adjacent structures. An encapsulated mass was totally removed. Pathological examination revealed a well-differentiated chondrosarcoma with chondrocyte atypias and neoplastic chondrocytes (Figures 3 and 4). No recurrence was seen in the 2-year followup. The approval of patient and institution were taken to use their records for our study. Written informed consent was obtained from the patient for publication of this case report and accompanying images.

fig3
Figure 3: Photomicrograph of the resected tumor showing (Hematoxylin and Eosin, ×100) the well-differentiated chondrosarcoma with chondrocyte atypias and neoplastic chondrocytes.
fig4
Figure 4: Photomicrograph of the resected tumor showing (Hematoxylin and Eosin, ×400) increased cellularity, marked atypia, and pleomorphism; mitosis.

3. Conclusions

Chondrosarcomas are presumably derived from primitive precartilaginous mesenchymal cells [3]. It may occur in extraskeletal locations and mainly in the soft tissues of the orbit, the cranial and spinal meningeal coverings, and lower limbs [4]. Primary chondrosarcoma of the anterior mediastinum without any continuity with cartilage-containing organs are extremely rare. In the present case, chondrosarcoma was located on anterior mediastinum and extraskeletal.

Chondrosarcoma is more frequently found in patients from the fourth to seventh decades, with a male predominance [2, 5]. Local pain is the most frequent presenting symptom of patients with this neoplasm [1, 6, 7]. Precordial chest pain was main symptom in our case. Also, the mass lesion was marked compressing on the heart.

Chest radiography, thorax CT, and MRI depicts lobulated, well-shaped soft tissue mass, as in our case. Mediastinal chondrosarcomas also shares imaging findings with other skeletal and soft-tissue tumors. Brenner et al. reported that the combination of pSUV on PET imaging and histopathologic tumor grading in chondrosarcoma might be helpful for determining a more accurate diagnosis [8]. Histopathologic examination shows chondrocyte atypias and neoplastic chondrocytes, as seen in our case.

The wide local excision is recommended for treatment. In the present case, mediastinal chondrosarcoma was totally resected. The patient did not receive radiotherapy because all the surgical margins were tumor-free. According to reported one article, the primary chondrosarcomas of anterior mediastinum may have a less aggressive clinical course than previously recognized [3]. There is no recurrence during two years after surgery. Burt et al. reported that the 47 primary sarcomas of the mediastinum and mediastinal chondrosarcoma was seen in only one patient. Also, factors significantly affecting survival were tumor grade and radicality of resection [9].

In conclusion, the extraskeletal chondrosarcoma in anterior mediastinum is very rare and usually overlooked on chest radiography. The complete surgical excision is enough for treatment, and prognosis is better than other chondrosarcomas.

Consent

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Conflict of Interests

The authors declare that they have no conflict of interests.

Authors’ Contribution

S. Ozkaya, K. Furtun, C. Yuksel, A. Dirican, and S. Findik have made substantial contribution to conception and design, or acquisition of data, or analysis and interpretation of data.

References

  1. G. W. Gladish, B. M. Sabloff, R. F. Munden, M. T. Truong, J. J. Erasmus, and M. H. Chasen, “Primary thoracic sarcomas,” Radiographics, vol. 22, no. 3, pp. 621–637, 2002. View at Scopus
  2. O. Cakir, U. Topal, A. S. Bayram, and S. Tolunay, “Sarcomas: rare primary malignant tumors of the thorax,” Diagnostic and Interventional Radiology, vol. 11, no. 1, pp. 23–27, 2005. View at Scopus
  3. G. B. Ratto, R. Costa, A. Alloisio, P. Maineri, P. Ceppa, and M. Chiaramondia, “Mediastinal chondrosarcoma,” Tumori, vol. 90, no. 1, pp. 151–153, 2004. View at Scopus
  4. L. G. Shapeero, D. Vanel, D. Couanet, G. Contesso, and L. V. Ackerman, “Extraskeletal mesenchymal chondrosarcoma,” Radiology, vol. 186, no. 3, pp. 819–826, 1993. View at Scopus
  5. Y. C. Fong, P. C. Pairolero, F. H. Sim, S. S. Cha, C. L. Blanchard, and S. P. Scully, “Chondrosarcoma of the chest wall: a retrospective clinical analysis,” Clinical Orthopaedics and Related Research, no. 427, pp. 184–189, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. P. K. Hsu, H. S. Hsu, H. C. Lee et al., “Management of primary chest wall tumors: 14 years' clinical experience,” Journal of the Chinese Medical Association, vol. 69, no. 8, pp. 377–382, 2006. View at Scopus
  7. L. Ollivier, D. Vanel, and J. Leclère, “Imaging of chondrosarcomas,” Cancer Imaging, vol. 4, pp. 36–38, 2003.
  8. W. Brenner, E. U. Conrad, and J. F. Eary, “FDG PET imaging for grading and prediction of outcome in chondrosarcoma patients,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 31, no. 2, pp. 189–195, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Burt, J. K. Ihde, S. I. Hajdu et al., “Primary sarcomas of the mediastinum: results of therapy,” Journal of Thoracic and Cardiovascular Surgery, vol. 115, no. 3, pp. 671–680, 1998. View at Publisher · View at Google Scholar · View at Scopus