Giant Cell Tumor of Bone: Documented Progression over 4 Years from Its Origin at the Metaphysis to the Articular Surface

Figure 5

Microscopic examination of curettage specimen. (a) Aneurysmal bone cyst-like area with blood-filled spaces lined by fibrous septa containing reactive bone (blue arrows) and hemosiderin (green arrow head); H&E stain at 40x and at 400x (b) demonstrating giant cell tumor areas with multinucleated giant cells evenly dispersed amongst mononuclear cells with spindled morphology. No overt or diffuse nuclear pleomorphism is identified and while scattered mitotic figures are present (arrow head), no atypical forms are seen.

(a)

(b)