A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
Figure 2
Histopathological and histoimmunochemical features of lymph node biopsy. Lymph node biopsy showed follicular hyperplasia and germinal center proliferation with narrowed mantle-zone ((a): HE stain, ×20). No dysplasia was seen in germinal center and hemophagocytic cells are scattered in this area ((b): HE stain, ×100). The lymphocytes forming in the germinal center were CD20 positive (c), BCL-2 negative (d), and IL-6 positive (e). Plasmacytes in interfollicular area were also IL-6 positive (f).
