Case Report
Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
Table 1
Sequential changes of liver enzymes and laboratory tests for hepatitis E.
| Time after admission | AST | ALT | Anti-HEV IgG | Anti-HEV IgM | Anti-HEV IgA | HEV RNA | (13–33 IU/L∗) | (6–27 IU/L∗) | (OD450 < 0.175∗) | (OD450 < 0.440∗) | (OD450 < 0.642∗) | (−) |
| −30 months | 17 | 9 | 0.046 | 0.043 | 0.042 | − | −20 months | 16 | 14 | 0.047 | 0.05 | 0.035 | − | −10 months | 19 | 14 | 0.035 | 0.088 | 0.04 | − | 0 | 338 | 523 | 2.563 | 2.845 | 2.93 | + | 1 week | 44 | 137 | 2.822 | >3.000 | >3.000 | + | 2 weeks | 32 | 37 | >3.000 | 2.894 | 2.296 | + | 3 weeks | 22 | 18 | 2.748 | 2.771 | 1.499 | + | 6 weeks | 27 | 25 | 2.956 | 2.661 | 1.113 | − | 10 weeks | 22 | 15 | >3.000 | 2.303 | 1.019 | − | 14 weeks | 27 | 19 | >3.000 | 1.863 | 0.799 | − | 22 weeks | 43 | 28 | >3.000 | 1.022 | 0.536 | − | 26 weeks | 31 | 26 | NA | NA | NA | NA | 57 months | 24 | 17 | 1.659 | 0.176 | 0.115 | − |
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∗Normal range. HEV, hepatitis E virus; IgG, immunoglobulin G; IgM, immunoglobulin M; IgA, immunoglobulin A; NA, not available.
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