A Case of Severe Seronegative Inflammatory Arthritis due to Nivolumab and Review of the Literature

Table 1

Immunologic workup.

Immunology/serology	Reference range	Result
ANA	Negative	Positive
ANA titer	Negative	1 : 160
ANA pattern	Unknown	Nucleolar
DNA antibody	<30 IU/mL	22
RNP antibody	<1.0	<0.2
Ribosomal RNP	<1.0	<0.2
SSB antibody	<1.0	<0.2
Sm antibody	<1.0	<0.2
SSA antibody	<1.0	<0.2
Scleroderma Ab, IgG	<1.0	<0.2
Jo 1 antibody	<1.0	<0.2
Chromatin antibody	<1.0	<0.2
Centromere Ab	<1.0	<0.2
Rheumatoid factor	<16 IU/mL	<10
CCP antibody, IgG	<20 units	<15

ANA: antinuclear antibody; DNA: deoxyribonucleic acid; RNP: ribonucleoprotein; SSB: anti-Sjögren’s syndrome type B; SSA: anti-Sjögren’s syndrome type B; Ab: antibody; CCP: cyclic citrullinated peptide; IU: international unit.