Nephrotic Syndrome due to Focal Segmental Glomerulosclerosis Complicating Sjögren’s Syndrome: A Case Report and Literature Review

Figure 1

Histopathological findings in a kidney biopsy specimen showing collapse of capillary loop and segmental sclerosis with proliferation of glomerular epithelial cells. (a) Hematoxylin-eosin staining, high magnification. Intraluminal cell proliferation or necrotizing crescentic formation is not shown. (b) Periodic acid-Schiff staining, high magnification. Mesangial matrix proliferation or mesangial cell proliferation is not shown. (c) Periodic acid-methenamine-silver staining, low magnification. (d) Periodic acid-methenamine-silver staining, high magnification. A segmental lesion is observed at the tubular pole. (e) Periodic acid-methenamine-silver staining, low magnification. (f) Periodic acid-Schiff staining. Although there was slight lymphocytic infiltration in the tubulointerstitial area, obvious tubulointerstitial nephritis was not detected.

(a)

(b)

(c)

(d)

(e)

(f)