Spontaneous Pneumomediastinum due to Anti-Melanoma Differentiation-Associated Protein 5 Requiring a Bilateral Lung Transplant

Table 1

Lung transplant rescue therapy in MDA5-RPILD case reports.

Reference	Country	Patient demographics	Clinical features	Positive biomarkers	Outcome
Deitchman et al. [16]	USA	51-year-old male	Small joint arthralgias, cough, dyspnea	Anti-MDA5	Bilateral lung transplant
Huang et al. [1]	Canada	52-year-old male	Heliotrope rash, Gottron’s papule, periungal erythema	Anti-RO52, anti-MDA5	Bilateral lung transplant
Huang et al. [1]	Canada	54-year-old female	Heliotrope rash, Gottron’s papule, cutaneous ulcers	Anti-RO52, anti-MDA5, OJ	Bilateral lung transplant
Huang et al. [1]	Canada	59-year-old female	Palmar papules, periungal erythema	Anti-RO52, anti-MDA5	Bilateral lung transplant
Leclair et al. [8]	USA	38-year-old male	Heliotrope rash, Gottron’s papules, periungal erythema, buccal mucosa erosions, mechanic’s hands, arthralgia, exertional dyspnea	Anti-RO52, anti-MDA5	Bilateral lung transplant
Takada et al. [17]	USA	42-year-old female	Rash to the face and hands, leg weakness, dyspnea	Anti-smooth-muscle antibody, serum IgG,	Bilateral lung transplant
Pacot et al. [7]	France	51-year-old male	Acute dyspnea	Anti-MDA5, cytoplasmic islets	Bilateral lung transplant
Shoji et al. [18]	Japan	52-year-old female	Gottron’s papules, dyspnea	Anti-MDA5	Bilateral lung transplant