Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time

Figure 3

Histopathological findings. (a) On gross examination, the cut surface shows a solitary, well-circumscribed but unencapsulated lesion; at the periphery, multiple dark-brown nodules are interspersed with the fibrotic stroma. (b) At low magnification, the lesion consisted of multiple angiomatoid nodules in a fibrotic stroma, with sharp demarcation from the adjacent splenic parenchyma (right). (c) Vascular component within nodules composed by small-sized blood vessels, with slit-like, round, or irregular shape; an incomplete fibrinoid rim was present at the periphery of this angiomatoid nodule. (d) The internodular tissue consisted of dense fibrous tissue with myxoid areas with siderophages and scattered plump myofibroblasts, plasma cells, and lymphocytes. Original magnifications—b: ×10; c and d: ×200.

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