Primary Angiosarcoma of the Breast after Bilateral Breast Reduction

Figure 4

(a) 2x H&E stain. Skin with hyperkeratosis and underlying dermis containing nodular areas of poorly formed vascular spaces. (b) 2x H&E stain. Breast tissue composed of glands and adipose tissue with invasion by angiosarcoma. (c) 10x H&E stain. Infiltrating atypical spindle cells in a nodular pattern making poorly formed vascular channels with extravasated red blood cells. (d) 40x H&E stain. Atypical spindle endothelial cells with pleomorphic, large irregular nuclei, with prominent nucleoli, and multiple mitotic figures. There are red blood cells inside poorly formed vascular lumens as well as surrounding the spindle cells.

(a)

(b)

(c)

(d)