493758.fig.002a
(a)
493758.fig.002b
(b)
Figure 2: (a) FLAIR axial sequence of MRI of brain with gadolinium showing a large lesion in the right basal ganglia and frontal lobe with extensive edema and mass effect in keeping with a fungal abscess. (b) Brain biopsy (i). Representative area of the brain biopsy shows relatively acellular necrotic material in the top 1/5 of the image, the dense pink well-formed capsule, of a chronic abscess, occupying the bottom 1/3 of the image and a looser admixture of lymphocytes, macrophages, and new blood vessels in the center of the field. Hematoxylin and eosin, original magnification 100x (ii). The dark black structures forming a linear array running obliquely from top left to bottom center are fragments of fungi. Gomori Methenamine Silver, original magnification 400x (iii). The arrow indicates a single black fragment of a fungal structure with 45-degree branching, which is characteristic of aspergillus. Gomori Methenamine Silver, original magnification 600x.