About this Journal Submit a Manuscript Table of Contents
Case Reports in Transplantation
Volume 2012 (2012), Article ID 825289, 6 pages
http://dx.doi.org/10.1155/2012/825289
Case Report

Therapeutic Potential of Autologous Stem Cell Transplantation for Cerebral Palsy

1StemOne Biologicals Pvt. Ltd., Gat No. 801, Urwade, Gadewadi, Tal-Mulshi, Pune 412108, India
2Shitole Hospital, Rajarampuri 1st Lane, Near Janata Bazar, Kolhapur 416008, India

Received 1 June 2012; Accepted 2 August 2012

Academic Editors: C. Costa and M. R. Moosa

Copyright © 2012 Chaitanya Purandare et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Cerebral palsy (CP) is a severe disabling disease with worldwide incidence being 2 to 3 per 1000 live births. CP was considered as a noncurable, nonreparative disorder, but stem cell therapy offers a potential treatment for CP. Objective. The present study evaluates the safety and efficacy of autologous bone-marrow-derived mononuclear cell (BMMNCs) transplantation in CP patient. Material and Methods. In the present study, five infusions of autologous stem cells were injected intrathecally. Changes in neurological deficits and improvements in function were assessed using Gross Motor Function Classification System (GMFCS-E&R) scale. Results. Significant motor, sensory, cognitive, and speech improvements were observed. Bowel and bladder control has been achieved. On the GMFCS-E&R level, the patient was promoted from grade III to I. Conclusion. In this study, we report that intrathecal infusion of autologous BMMNCs seems to be feasible, effective, and safe with encouraging functional outcome improvements in CP patient.