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Case Reports in Transplantation
Volume 2013 (2013), Article ID 309545, 4 pages
http://dx.doi.org/10.1155/2013/309545
Case Report

Acute Liver Failure Occurring during the First Trimester of Pregnancy Successfully Treated with Living Donor Liver Transplantation

1Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan
2Department of General Surgery, Chiba University, Graduate School of Medicine, Chuo-ku, Chiba 260-8677, Japan
3Department of Reproductive Medicine, Chiba University, Graduate School of Medicine, Chuo-ku, Chiba 260-8677, Japan
4Department of Emergency and Critical Care Medicine, Chiba University, Graduate School of Medicine, Chuo-ku, Chiba 260-8677, Japan

Received 1 October 2013; Accepted 13 November 2013

Academic Editors: D. Capone, C. F. Classen, C. Costa, and F. Keller

Copyright © 2013 Naoya Kanogawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute liver failure (ALF) during pregnancy remains difficult to treat, and despite advances in treatment, liver transplantation must be selected as treatment option in certain cases. We report a 30-year-old woman with ALF of unknown etiology, occurring during the first trimester of pregnancy. Her condition was complicated by consciousness disturbance and coagulopathy due to ALF, but she was successfully treated with living donor liver transplantation 7 days after dilatation and curettage. At 9-month followup, she was in good medical condition. Liver transplantation has been reported as one of the treatment options for ALF during pregnancy with the prognosis varying depending on the trimester, from living donor or deceased donor liver transplantation. Of importance is that clinicians always think of emergent liver transplantation as a therapeutic option in ALF even in the first trimester of pregnancy.