905743.fig.003a
(a)
905743.fig.003b
(b)
Figure 3: Electron microscopical changes in kidney (a) and native lung (b) biopsies. Glomerular podocytes (P) show extensive accumulation of “myeloid” and “zebroid” bodies (arrows) characteristics of Fabry diseases. However, capillary loops (CL) remain open, and endothelial cells (E) do not exhibit morphological changes. Ciliated pulmonary epithelial cells show an increase and accumulation of irregularly shaped inclusions in lysosomes and autophagosomes consistent with storage of sphingolipids (arrows).