Utility of Iron Staining in Identifying the Cause of Renal Allograft Dysfunction in Patients with Sickle Cell Disease

Figure 3

Native renal biopsy with sickle cell nephropathy associated iron deposition and acute tubular injury. A 17-year-old male, with a medical history of SCD, developed acute renal failure. Findings of his renal biopsy were consistent with SCN. Top panel: the proximal tubules were deposited with large amount of iron broken from sickle red blood cells (positive Prussian blue iron staining). Bottom panel: the iron-associated nephrotoxicity in the proximal tubules was confirmed by positive KIM-1 staining. (Top and bottom panels, original magnification ×400.)