Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide

Table 2

Detailed demographics and outcomes of kidney transplants in patients with SBS.

Case	Age	Sex	Cause of SBS	Cause of kidney disease	Transplant	Immunosuppression	Follow-up (years)	eGFR (ml/min)	Complications
1 [16]	64	M	Mesenteric thrombosis	Oxalate nephropathy	DDKT	Pred, Aza	0.83	55	Acute rejection
2 [17]	62	F	Intestinal obstruction	Oxalate nephropathy	DDKT	Pred, Aza	7	80	Cryptococcus neoformans infection
3 [18]	74	M	Bowel resection (Crohn’s)	Oxalate nephropathy	Unknown	Unknown	3	36	Oxalate deposition
4 [19]	27	M	Ileocolic resection	Congenital urological	DDKT	Pred, MMF, Rapa	1	122	None
5 [20]	40	M	Bowel resection (Crohn’s)	Oxalate nephropathy	DDKT	Pred, MMF, Tacro, Rapa	2	14	DGF, oxalate deposition
6 [6]	18	M	Necrotizing enterocolitis	Focal GS	LDKT	M-Pred, MMF, CsA	5	22	Acute rejection, dehydration, acidosis
7 [14]	50	F	Obstruction, EC fistulae	Tacrolimus toxicity	LDKT	Pred, MMF, Tacro	2.1	38	None
8 [2]	38	F	Bowel resection (Crohn’s)	Nephrolithiasis	LDKT	Unknown	7	0	Oxalate deposition, IFTA
9 [2]	44	F	Bowel resection (Crohn’s)	Oxalate nephropathy	LDKT	MMF, Tacro	1	61	None
10 [2]	49	M	Bowel resection (Crohn’s)	Oxalate nephropathy	DDKT	Unknown	3	71	None
11 [2]	47	F	Bowel resection (Crohn’s)	Nephrolithiasis	DDKT	Unknown	2	19	Oxalate deposition, GS, tubular atrophy
12 [5]	66	M	Bowel resection (Crohn’s)	Oxalate nephropathy	LDKT	Pred, MMF, Tacro	2.6	38	Sepsis at 2 months
13 [5]	63	M	Bowel resection (Crohn’s)	Nephrolithiasis	LDKT	Pred, MMF, Tacro	2.58	36	Chronic antibody-mediated rejection
14 [5]	63	M	Bowel resection (Crohn’s)	Oxalate nephropathy	DDKT	Pred, MMF, Tacro	2.25	31	Recurrent urinary tract infections
15 [5]	60	F	Bowel resection (Crohn’s)	Nephrosclerosis	DDKT	Pred, MMF, Tacro	1.16	99	Delayed graft function, TMA
16 [5]	53	F	Bowel resection (Crohn’s)	Unknown	DDKT	Pred, MMF, Tacro	1.16	37	Dehydration, ATN
17 [5]	67	M	Bowel resection (Crohn’s)	Nephrolithiasis	DDKT	Pred, MMF, Tacro	1	35	MI, hydro, recurrent UTIs, ATN
18 [5]	72	M	Bowel resection (Crohn’s)	Unknown	DDKT	Pred, MMF, Tacro	0.25	69	None
19 [5]	53	M	Bowel resection (Crohn’s)	Focal GS	LDKT	Pred, MMF, Tacro	0.04	0	Sepsis, ATN, multiorgan failure, & death
Current	59	M	Bowel resection (Crohn’s)	Unknown	DDKT	Pred, Aza, Tacro	2.6	67	DGF, ATN, oxalate deposition

eGFR at last follow-up was generated using CKD-EPI formula when serum creatinine was available; Caucasian race was assumed if race was not available. ATN: acute tubular necrosis; Aza: azathioprine; DDKT: deceased donor kidney transplant; DGF: delayed graft function; EC: enterocutaneous; GS: glomerulosclerosis; Hydro: hydronephrosis; IFTA: interstitial fibrosis and tubular atrophy; LDKT: living donor kidney transplant; MI: myocardial infarction; MMF: mycophenolate mofetil; Pred: prednisone; Rapa: rapamycin; Tacro: tacrolimus; UTI: urinary tract infection.